
Oxeia Biopharma
OperatingOxeia Biopharmaceuticals, Inc.
Biotech · Boston, MA
Millions of Americans suffer concussions each year. 1.4 to 4.2 million may never recover. Rest is not enough—and there are zero FDA-approved treatments. OXE103 is a first-in-class ghrelin therapy that showed an 85% responder rate in a Phase 2a trial. Supported by NFL quarterback Alex Smith and cornerback Richard Sherman, backed by $100+ million in development data by Daiichi Sankyo, and led by a team whose prior companies have achieved $9 billion in exits.
Financials
FY2023–FY2024 · from SEC filings · hover any figure for its sourceFigures as reported by the issuer in the filing shown on hover. Each year’s pill shows the assurance level of its filed statements — audited, reviewed (CPA review, less than an audit), or unaudited, as the filing’s own report or certification states it. A dashed pill marked * is inferred instead: the SEC minimum for an offering that size, which the issuer may have exceeded. No pill means we couldn’t tell. Headcount is the filing’s point-in-time count, not a year-end average. Manually corrected figures are marked “Corrected”.
Valuation over rounds
Pre-money — the valuation set before each round’s money came inBlue bars are the pre-money valuation the company stated for a priced round.
Fundraising history
Team
14 people
Served as President and CEO of Arena Pharmaceuticals from 2016 until its $6.7 billion acquisition by Pfizer in 2022. At Arena, he advanced multiple drug candidates through clinical development, including etrasimod (now Velsipity) for ulcerative colitis. Previously held leadership roles at Amgen, Kythera Biopharmaceuticals (acquired by Allergan for $2.1 billion), and Percivia (acquired by Johnson & Johnson). Brings 25+ years of experience in clinical development and portfolio management.

Co-founded Oxeia and negotiated the licensing agreement that secured access to over $100+ million in completed preclinical, manufacturing, and clinical development data generated by Daiichi Sankyo. Led Oxeia's fundraising and operations, overseeing strategy, licensing, and intellectual property. Previously held commercial strategy roles at Atara Biotherapeutics and corporate strategy and post-merger positions at Amgen. He currently serves as Chief Business Officer at Tactile Therapeutics, a discovery stage neuroscience company.

Led drug development programs at Epirus, BioAssets, and Therion Biologics, where he advanced Prostvac through Phase 2 clinical development. Brings 30 years of experience navigating FDA regulatory pathways and positioning biotech companies for strategic exits. His expertise spans early clinical trials through commercialization across multiple therapeutic areas.

Trauma surgeon at Scripps Mercy Hospital in San Diego and inventor of OXE103. His research at UCSD, the American Association of Trauma (AAST), and the American Surgical Association (ASA) discovered that ghrelin, a naturally occurring peptide hormone, reduces oxidative stress, prevents blood-brain barrier breakdown, and restores neural function following traumatic brain injury. Published in Journal of Neurotrauma, Brain Research, Inflammation, and Journal of Surgical Research, with clinical studies published in Neurotrauma Reports.

16-year NFL career. 3× Pro Bowl. 2020 NFL Comeback Player of the Year. ESPN analyst. Suffered a career-altering concussion in 2012 that cost him his starting position with the San Francisco 49ers. After witnessing teammates struggle with persistent post-concussion symptoms for months and years—with no treatment options available—he joined Oxeia as both investor and board member to help bring potentially the first FDA-approved therapy to market.

Chair of the Department of Neurosurgery at Duke University School of Medicine. NIH-funded investigator with active research programs in brain tumors, focused ultrasound, and concussion. Previously served as chief of pediatric neurosurgery at Stanford and as U.S. Air Force combat neurosurgeon deployed to Iraq during Operation Iraqi Freedom. Author of over 300 peer-reviewed publications.

Associate Professor of Neurology at University of Kansas Medical Center and Medical Director of the Center for Concussion Management at The University of Kansas Health System. Principal Investigator for Oxeia's Phase 2a study, which demonstrated an 85% responder rate in persistently symptomatic concussion patients. Sports neurologist specializing in concussion treatment and long-term brain health optimization in athletes. Research focuses on novel treatments, sleep disturbances following concussion, and interdisciplinary care approaches.

Distinguished Professor of Psychiatry and Family & Preventive Medicine at University of California San Diego (UCSD) and Vice Chair for Clinical Research in Psychiatry. Staff Psychiatrist at VA San Diego Healthcare System and Director of the Anxiety & Traumatic Stress Disorders Program. Principal Investigator and Director of the Department of Defense-funded INTRuST Consortium, which conducts research on treatments for PTSD and traumatic brain injury in veterans. Published over 800 peer-reviewed articles in journals including NEJM, Lancet, and JAMA. Member of the FDA Psychopharmacologic Drugs Advisory Committee.
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Co-founder and CEO of the Concussion & CTE Foundation. Former Harvard football player and WWE professional wrestler who developed career-ending post-concussion syndrome in 2003. Authored Head Games: Football's Concussion Crisis (2006), which documented the NFL's systematic minimization of concussion risks. Co-founded Boston University's CTE Center and UNITE Brain Bank, the world's largest resource for CTE research. Earned his doctorate in Behavioral Neuroscience from Boston University and has published over 50 scientific papers.

11-year NFL veteran. 5× Pro Bowl. 3× All-Pro. Super Bowl XLVIII Champion. Sustained a concussion during his 2011 rookie season and played through blurred vision—a decision he has since said he regrets. Now serves as one of the NFL's most vocal advocates for brain health and player safety, joining Oxeia to help advance the potential first treatment for persistent concussion symptoms.

Former CEO of Pulmatrix, a clinical-stage biopharmaceutical company developing inhaled therapies for respiratory diseases. Previously served as Chief Commercial Officer at Option Care, where he helped separate the specialty home infusion business unit from Walgreens to create the nation's largest independent home infusion provider. Earlier held senior commercial positions at Sunovion, launching multiple respiratory and central nervous system products and establishing strategic alliances in the US and Japan.
Names and titles as disclosed on StartEngine, SEC Form C. Bios and photos come from the platform campaign page and may be out of date.
Reg CF annual-report compliance
Filed 0 of 1 annual reports (FY2025)
Missing: 2025
Reg CF issuers must file a Form C-AR each year until a Rule 202(b) termination trigger is met.
SEC filings
View all 10 filings on EDGAR- Form C-USep 28, 20260001610315-26-000018EDGAR
- Form C/ASep 21, 20260001610315-26-000017EDGAR
- Form C/AAug 14, 20260001610315-26-000014EDGAR
- Form C/AJul 21, 20260001610315-26-000011EDGAR
- Form C/AMay 26, 20260001610315-26-000010EDGAR
- Form C/AApr 3, 20260001610315-26-000008EDGAR
- Form C/AApr 2, 20260001610315-26-000007EDGAR
- Form C/AJan 15, 20260001610315-26-000005EDGAR
About this data. Figures are compiled from public sources — SEC EDGAR filings (Form C, C-AR, 1-A, 1-K) and funding-platform pages — and may be delayed, incomplete, or restated by the issuer. Financial statements are as reported by the issuer; each year is labeled with its assurance level (audited / reviewed / unaudited). A valuation cap is the conversion ceiling of a SAFE or convertible note, not an agreed company valuation; post-money figures are computed as pre-money plus amount raised and are not a traded price. Crowdonomics is not a broker-dealer, funding portal, or investment adviser; nothing here is investment advice or an offer to sell securities. Verify all figures against the linked EDGAR filings.